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Assignment: Pharmacotherapy for Cardiovascular Disorders

Heart disease remains the No. 1 killer in America; nearly half of all Americans have high blood pressure, high cholesterol, or smokesome of the leading risk factors for heart disease
Murphy et al., 2018
Despite the high mortality rates associated with cardiovascular disorders, improved treatment options do exist that can help address those risk factors that afflict the majority of the population today. 

As an advanced practice nurse, it is your responsibility to recommend appropriate treatment options for patients with cardiovascular disorders. To ensure the safety and effectiveness of drug therapy, advanced practice nurses must consider aspects that might influence pharmacokinetic and pharmacodynamic processes such as medical history, other drugs currently prescribed, and individual patient factors.
Reference: Murphy, S. L., Xu, J., Kochanek, K. D., & Arias, E. (2018). Mortality in the United States, 2017. Retrieved from
To Prepare
    Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.
    Review the case study assigned by your Instructor for this Assignment.
    Select one the following factors: genetics, gender, ethnicity, age, or behavior factors.
    Reflect on how the factor you selected might influence the patients pharmacokinetic and pharmacodynamic processes.
    Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patients recommended drug therapy.
    Think about how you might improve the patients drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.

Write a 2- to 3-page paper that addresses the following:
    Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned.
    Describe how changes in the processes might impact the patients recommended drug therapy. Be specific and provide examples.
    Explain how you might improve the patients drug therapy plan and explain why you would make these recommended improvements.


Patient HM has a history of atrial fibrillation and a transient ischemic attack (TIA). The patient has been diagnosed with type 2 diabetes, hypertension, hyperlipidemia and ischemic heart disease. Drugs currently prescribed include the following:
    Warfarin 5 mg daily MWF and 2.5 mg daily T, TH, Sat, Sun
    Aspirin 81 mg daily
    Metformin 1000 mg po bid
    Glyburide 10 mg bid
    Atenolol 100 mg po daily
    Motrin 200 mg 13 tablets every 6 hours as needed for pain

Reminder: The College  requires that all papers submitted include  introduction and summary.

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